OXYMETHOLONE – one of the strongest AAS ever

Oxymetholone is a very strong substance belonging to the group of anabolic androgenic steroids. It is also known as Anapolon, common name is Anadrol®-50 or Anapolon-50 - where the number 50 is the dose in mg (per tablet). It is one of the strongest AAS available on the market. Exactly the same rule applies in its case as for other C17-alpha alkylated AAS - they can be extremely toxic to the liver (the same problem is with Metandienone, Stanozolol, Oral turinabol or Halotestin, to a lesser extent: Oxandrolone / Anavar).

Chemical formula: 17beta-hydroxy-2-[hydroxymethylene]-17-methyl-5alpha-androstan-3-one

Oxymetholone – chemical structure and functioning

Oxymetholone is protected before the first passage through its methylation. In pharmacology this effect is a parameter used to specify how much of the substance is lost in contact with the liver. Alkylation at position 17 (methyl) protects against the first pass effect, increasing its toxicity to the liver. If the steroids are fed orally, then during the first contact with the liver some percentage of the drug is lost. In case of injection the losses are usually much smaller (of course, the liver also metabolizes AAS injection so for example administration of Metandienone or Winstron in the form of injections does not prevent you from possible liver damage). The weakest assimilation have substances bereft of their alkylation Proviron(mesterolone) or Andriol (testosterone undecanoate, absorbed lymphatically). In short we can say that Oxymetholone is methylated derivative of DHT. But... this is where a huge difference takes place compared to other substances of this family. For example, Winstrol or Oxandrolone also are derivatives of DHT (dihydrotestosterone) - but with completely different properties.

Anapolon's most distinctive feature is the presence of the 2-hydroxymethylene group which significantly increases the strength of that preparation and is unparalleled in other AAS [1]. Due to its chemical structure Oxymetholone is a close relative of Mestanolone (methylated dihydrotestosterone).

Let's compare:

Aromatization (conversion to estrogen):

  • Winstrol - no,
  • Anapolon - yes, strong,

Water Retention:

  • Winstrol - no,
  • Anapolon - yes, strong,

Large weight gain:

  • Winstrol - no,
  • Anapolon - yes (also associated with water retention).

Hepatic toxicity:

  • Winstrol - yes, it depends on the dose and use of other drugs,
  • Anapolon - yes, it depends on the dose and use of other drugs,

Application directly before the competition:

  • Winstrol - yes,
  • Anapolon - usually not,

Strength increase:

  • Winstrol - yes, it depends on the dose and use of other drugs,
  • Anapolon - yes, it depends on the dose and use of other drugs,


  • Winstrol - no,
  • Anapolon - possibly,

Joint "dryness":

  • Winstrol - yes, strong,
  • Anapolon - no,

To sum up: Anapolon can be considered "mass steroid", while Winstrol (to simplify) a "qualitative drug". Of course, this is vague and confusing because mass increase depends mostly on your diet and weight training. Besides, any kind of substance can be used for a variety of purposes. Winstrol suits ideally to all: building mass, increasing strength and improving definition (of course, not used alone but in combination with other drugs).

Anapolon: toxic or not? Renal infraction after 50mg of Anapolon

Anapolon can be toxic not only to the liver, but also... to kidneys. In one study published in 2014 in "QJM: An International Journal of Medicine" [2] a 40 year old man was admitted to hospital with severe pain in the lower back. The pain came 24 hours before the admission to the hospital. He didn't complain about any other ailment. The man turned out to be a weightlifter. He pleaded he didn't use any medication.